Shanger Wang,Robert J. Boock,Andrew Trinin Dennis,Ted Tang Lee,Jeff T. Suri,David Sze,Mark A Tapsak,Huashi Zhang,Jiong Zou
申请号：
US15395892
公开号：
US20170188916A1
申请日:
2016.12.30
申请国别(地区):
US
年份:
2017
代理人:
摘要：
Disclosed are devices for determining an analyte concentration (e.g., glucose). The devices comprise a sensor configured to generate a signal associated with a concentration of an analyte and a sensing membrane located over the sensor. The sensing membrane comprises a biointerface layer which interfaces with a biological fluid containing the analyte to be measured. The biointerface layer can comprises a biointerface polymer, wherein the biointerface polymer comprises polyurethane and/or polyurea segments and one or more zwitterionic repeating units. The sensing membrane can also comprise an enzyme layer, wherein the enzyme layer comprises an enzyme and a polymer comprising polyurethane and/or polyurea segments and one or more zwitterionic repeating units. The sensing membrane can also comprise a diffusion-resistance layer, which can comprise a base polymer having a lowest Tg of greater than −50 C.
