John C. Williams,Cindy Zer,Kendra N. Avery,Ulrich Rodeck,Joshua M. Donaldson,Csaba Kari
申请号：
US16460957
公开号：
US20200164077A1
申请日:
2019.07.02
申请国别(地区):
US
年份:
2020
代理人:
摘要：
In one embodiment, a masked monoclonal antibody (mAb) is provided, the mAb, encoded by a nucleic acid sequence or an amino acid sequence molecule comprising a signal sequence, a masking epitope sequence, a linker sequence that is cleavable by a protease specific to a target tissue； and an antibody or a functional fragment thereof. In another embodiment, a masked monoclonal antibody (mAb) is provided, which includes a therapeutic mAb and a mask, the mask comprising protein A and protein L attached by a protease cleavable linker.
