Amy Sze Pui Tam;Marion T. Kasaian;Lioudmila Gennadievna Tchistiakova;Nancy ;Kimberly Ann Marquette;Debra D. Donaldson;Laura Long Lin;Geertruida Machteld Veldman;Eric Feyfant;Xiang-Yang Tan;Tania Shane
发明人:
Marion T. Kasaian,Lioudmila Gennadievna Tchistiakova,Geertruida Machteld Veldman,Kimberly Ann Marquette,Xiang-Yang Tan,Debra D. Donaldson,Laura Long Lin,Tania Shane,Amy Sze Pui Tam,Eric Feyfant,Nancy
申请号：
US12575896
公开号：
US08221752B2
申请日:
2009.10.08
申请国别(地区):
US
年份:
2012
代理人:
摘要：
This application relates to antibodies, e.g., humanized antibodies, and antigen-binding fragments thereof, that bind to interleukin-13 (IL-13), in particular, human IL-13, and their uses in regulating immune responses mediated by IL-13. The antibodies disclosed herein are useful in diagnosing, preventing, and/or treating a subject, e.g., a human patient, one or more IL-13-associated disorders, e.g., respiratory disorders (e.g., asthma)； atopic disorders (e.g., allergic rhinitis)； inflammatory and/or autoimmune conditions of the skin (e.g., atopic dermatitis), and gastrointestinal organs (e.g., inflammatory bowel diseases (IBD)), as well as fibrotic and cancerous disorders.
