CHUANG, WOEI JER,庄伟哲,莊偉哲,FU, WEN MEI,符文美,符文美,HUANG, YEN LUN,黄嬿伦,黃嬿倫
申请号：
TW099145616
公开号：
TWI581801B
申请日:
2010.12.23
申请国别(地区):
TW
年份:
2017
代理人:
摘要：
The invention generally relates to compositions and methods of treatment and/or prevention of angiogenesis-related eye diseases using low doses of rhodostomin variants, and in particular, low doses of a fusion protein comprising a rhodostomin variant, wherein the rhodostomin variant is conjugated with a variant of Human serum Albumin (HSA) where the cysteine residue at position 34 of the HSA amino acid sequence has been replaced with serine.本發明大體而言係關於使用低劑量之蛇毒蛋白(rhodostomin)變異體且尤其低劑量之包含蛇毒蛋白變異體的融合蛋白質來治療及/或預防血管新生相關之眼疾之組合物及方法,其中該蛇毒蛋白變異體與人類血清白蛋白(HAS)之變異體結合,其中該HSA胺基酸序列之位置34處的半胱胺酸殘基已經被絲胺酸置換。(無元件符號說明)
