The current invention relates to the intermittent dosing of an anti-CSF-1R antibody in combination with macrophage activating agent, corresponding pharmaceutical compositions or medicaments using such combination therapy.本發明係關於抗CSF-1R抗體和巨噬細胞活化劑組合之間歇性投藥、使用此組合療法之相應醫藥組合物或藥劑。