The invention discloses activation Wnt/ beta-catenin signal transduction and thus treatment or prevent with the beta-diketon of signal transduction related disease,γ-diketone or γ-hydroxy-ketone or its analog,The disease such as osteoporosis and osteoarthropathy； Osteogenesis imperfecta,Bony defect,Fracture,Periodontal disease,Otospongiosis,Wound healing,Craniofacial deformity,Oncolytic bone disease,Break up and develop relevant traumatic brain injury to central nervous system,Comprising Parkinson's disease,Apoplexy,Ischemic cerebrovascular disease,Epilepsy,Alzheimer disease,Depression,Bipolar disorders,Schizophrenia； The relevant macular degeneration of eye disease such as aging,Diabetic macular edema or retinal pigment degeneration and stem cell break up and generate relevant disease,Comprising alopecia,Hematopoietic related disorder and regeneration related disease.本發明公開了激活Wnt/β-聯蛋白信號轉導並且因而治療或防止與信號轉導相關疾病的β-二酮、γ-二酮或γ-羥基酮或其類似物，所述疾病例如骨質疏鬆和骨關節病；成骨不全、骨質缺損、骨折、牙周疾病、耳硬化症、傷口愈合、顱面畸形、溶瘤骨疾病、與中樞神經系統分化和發育相關的創傷性腦損傷，包含帕金森病、中風、缺血性腦血管病、癲癇、阿爾茨海默病、抑鬱症、雙相障礙、精神分裂症；眼病如衰老相關的黃斑變性、糖尿病黃斑水腫或視網膜色素變性和幹細胞分化及生成相關的疾病，包含脫髮，造血相關疾病和組織再生相關疾病。
