ФЛАВЕЛЛ, Ричард (US),СТРОВИГ, Тил (US),МАНЦ, Маркус Г. (CH),БОРСОТТИ, Кьяра (US),ДХОДАПКАР, Мадхав (US),МЁРФИ, Эндрю Дж. (US),СТИВЕНС, Шон (US),ЯНКОПУЛОС, Джордж Д. (US)
申请号：
RU2018140189
公开号：
RU2018140189A
申请日:
2013.11.05
申请国别(地区):
RU
年份:
2018
代理人:
摘要：
Genetically modified non-human animals are provided that may be used to model human hematopoietic cell development, function, or disease. The genetically modified non-human animals comprise a nucleic acid encoding human IL-6 operably linked to an IL-6 promoter. In some instances, the genetically modified non-human animal expressing human IL-6 also expresses at least one of human M-CSF, human IL-3, human GM-CSF, human SIRPa or human TPO. In some instances, the genetically modified non-human animal is immunodeficient. In some such instances, the genetically modified non-human animal is engrafted with healthy or diseased human hematopoietic cells. Also provided are methods for using the subject genetically modified non-human animals in modeling human hematopoietic cell development, function, and/or disease, as well as reagents and kits thereof that find use in making the subject genetically modified non-human animals and/or practicing the subject methods.
