Institute for Research in Biomedicine (IRB);Regeneron Pharmaceuticals Inc;Yale University
发明人:
Flavell, Richard,Strowig, Till,Manz, Markus G.,Borsotti, Chiara,Dhodapkar, Madhav,Murphy, Andrew J.,Stevens, Sean,Yancopoulos, George D.
申请号：
AU2019204775
公开号：
AU2019204775A1
申请日:
2019.07.03
申请国别(地区):
AU
年份:
2019
代理人:
摘要：
#$%^&*AU2019204775A120190725.pdf#####C: Interwoen NRPortbl DCC FMT 19020740_l.DOCX-2/07/2019 ABSTRACT Genetically modified non-human animals are provided that may be used to model human hematopoietic cell development, function, or disease. The genetically modified non-human animals comprise a nucleic acid encoding human IL-6 operably linked to an IL-6 promoter. In some instances, the genetically modified non-human animal expressing human IL-6 also expresses at least one of human M-CSF, human IL-3, human GM-CSF, human SIRPa or human TPO. In some instances, the genetically modified non-human animal is immunodeficient. In some such instances, the genetically modified non-human animal is engrafted with healthy or diseased human hematopoietic cells. Also provided are methods for using the subject genetically modified non-human animals in modeling human hematopoietic cell development, function, and/or disease, as well as reagents and kits thereof that find use in making the subject genetically modified non-human animals and/or practicing the subject methods.
