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Method for producing polypeptide heteromultimer
专利权人:
Chugai Seiyaku Kabushiki Kaisha
发明人:
Igawa, Tomoyuki,Katada, Hitoshi,Mimoto, Futa
申请号:
AU2014325063
公开号:
AU2014325063B2
申请日:
2014.09.26
申请国别(地区):
AU
年份:
2019
代理人:
摘要:
Provided is a method for producing a heteromultimer efficiently and stably by incubating under reducing conditions multiple types of homopolypeptides having a modification in the amino acids that form the interface of the Fc region and/or a modification to destabilize the stability of the heavy chain CH3 region introduced into the heavy chain CH3 region to achieve promotion of dissociation and/or control of association of the Fc region by utilizing charge repulsion.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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