Urosev, Dunja,Sanches, Mario,Tom-Yew, Stacey A.l.,Presta, Leonard G.
申请号：
AU2016334063
公开号：
AU2016334063A1
申请日:
2016.10.07
申请国别(地区):
AU
年份:
2018
代理人:
摘要：
Provided herein are multispecific antigen-binding polypeptide constructs comprising at least two different heterodimers, each comprising a heavy chain and a light chain. At least one heterodimer comprises a Fab region comprising a lambda light chain and at least one heterodimer comprises a Fab region comprising a kappa light chain. One or more of the immunoglobulin heavy and light chains that form the antigen-binding polypeptide construct comprise amino acid modifications that promote correct pairing between the heavy and light chains to form the desired multispecific antigen-binding polypeptide construct. The amino acid modifications may be in the C
