Bipartite inhibitors of bacterial RNA polymerase

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专利权人:

Richard H. Ebright

发明人:

Richard H. Ebright,Dongye Wang

申请号：

US12084018

公开号：

US08372839B2

申请日:

2006.11.04

申请国别(地区):

US

年份:

2013

代理人:

摘要：

The invention provides a compound having a structural formula (I): X-α-Y, wherein X is an moiety that binds to the Rif pocket of a bacterial RNA polymerase, Y is a moiety that binds to the secondary channel of a bacterial RNA polymerase, and α is a linker. The compound can act as an inhibitor of bacterial RNA polymerase. The invention has applications in control of bacterial gene expression, control of bacterial growth, antibacterial chemistry, and antibacterial therapy.

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