Yon Ebright;David Degen;Yu Zhang;Richard H. Ebright
发明人:
Richard H. Ebright,David Degen,Yu Zhang,Yon Ebright
申请号：
US14128391
公开号：
US20140206602A1
申请日:
2012.06.20
申请国别(地区):
US
年份:
2014
代理人:
摘要：
The invention provides bipartite inhibitors of bacterial RNA polymerase having the general structural formula (I): X-α-Y (I) wherein X is an moiety that binds to the rifamycin binding site of a bacterial RNA polymerase, Y is a moiety that binds to the GE23077 binding site of a bacterial RNA polymerase, and is a linker. The invention also provides compositions comprising such compounds, methods of making such compounds, and methods of using said compounds. The invention has applications in control of bacterial gene expression, control of bacterial growth, antibacterial chemistry, and antibacterial therapy.
