SHABANOWITZ, JEFFREY,NORRIS, ANDREW,CUMMINGS, KARA L.,ENGELHARD, VICTOR H.,ZARLING, ANGELA,OBENG, REBECCA C.,QIAN, JIE,COBBOLD, MARK,COTTINE, JENNIFER,ENGLISH, ANN M.,HUNT, DONALD F.
申请号:
EP11787229
公开号:
EP2576614A4
申请日:
2011.05.24
申请国别(地区):
EP
年份:
2013
代理人:
摘要:
A set of phosphorylated peptides are presented by HLA A*0101, A*0201, A*0301, B*4402, B*2705, B*1402, and B*0702 on the surface of melanoma cells. They have the potential to (a) stimulate an immune response to the cancer, (b) to function as immunotherapeutics in adoptive T-cell therapy or as a vaccine, (c) to facilitate antibody recognition of the tumor boundaries in surgical pathology samples, and (d) act as biomarkers for early detection of the disease. Phosphorylated peptides are also presented for other cancers.