Zoltan Timar,Zoltan Kupihar,Douglas J. Dellinger,Marvin H. Caruthers
申请号：
US11897898
公开号：
US08097711B2
申请日:
2007.08.31
申请国别(地区):
US
年份:
2012
代理人:
摘要：
Embodiments of the invention include nucleotide and nucleoside monomers protected at the 5′- or 3′-hydroxyls with thioether substituted aryl carbonate protecting groups. In certain cases, the carbonate protecting groups include an aryl moiety, e.g., a phenyl group, attached to the carbonate, where the aryl moiety further includes a thioether group, e.g., an alkyl or aryl thioether group, bound directly to the aryl ring. Aspects of the invention further include methods of synthesizing nucleic acids, e.g., oligonucleotides, using such protected nucleoside monomer monomers, as well as nucleic acids produced using methods of the invention and compositions thereof.
