PROTEINES DE FUSION DE FRAGMENTS DE PROTEINES HUMAINES NATURELLES POUR CREER DES COMPOSITIONS DE FC D'IMMUNOGLOBULINE MULTIMERISE DE FACON ORDONNEE

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专利权人:

GLIKNIK INC.

发明人:

BLOCK, DAVID S.,OLSEN, HENRIK

申请号：

CA2902942

公开号：

CA2902942A1

申请日:

2011.07.28

申请国别(地区):

CA

年份:

2012

代理人:

摘要：

The current invention involves a series of fully recombinant multimerizedforms ofimmunoglobulin Fc which thereby present polyvalent immunoglobulin Fc to immunecellreceptors. The fusion proteins exist as both homodimeric and highly orderedmultimericfractions, termed stradomers. In comparison to the homodimeric fraction,purified multimericstradomers have higher affinity and avidity for Fc.gamma.Rs with slowerdissociation and are useful inthe treatment and prevention of disease. The current invention demonstratesthat directly linkingIgG1 Fc regions to multimerization domains leads to enhanced multimerizationand biologicalactivity.

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中国工程科技知识中心

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