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Drugs and screening methods for Epstein-Barr virus related diseases
专利权人:
栄一;児玉
发明人:
児玉 栄一,松岡 雅雄,芦田 則之
申请号:
JP2009532175
公开号:
JP5326173B2
申请日:
2008.09.08
申请国别(地区):
JP
年份:
2013
代理人:
摘要:
1-(2-Fluoro-4-thio-²-D-arabinofuranosyl)-5-methyluracil exhibits an anti-EB virus activity, and is therefore effective as a prophylactic or therapeutic agent for a disease associated with an EB virus. Each of a plasmid capable of expressing EB virus-TK and a plasmid capable of expressing human-TK is introduced into a TK-defect cell, thereby producing two types of cells respectively having the plasmids introduced therein. By using the two types of cells, it is possible to screen a medicinal agent which has cytotoxicity against the cell having the plasmid capable of expressing EB virus-TK introduced therein but has no toxicity against the cell having the plasmid capable of expressing human-TK introduced therein. In this manner, it becomes possible to screen a medicinal agent which specifically exhibits an anti-EB virus activity.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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