A system and a method are provided for simulating a breast deformation of a subject using sensor data obtained from an orientation sensor of a mobile device, with the orientation sensor being configured for sensing an orientation of the mobile device with respect to a direction of gravity. In accordance with the system and method, model data is accessed which defines a biomechanical model of a breast. A simulation subsystem is provided for obtaining the sensor data from the orientation sensor of the mobile device and for determining a gravitational breast deformation by applying a gravitational force to the biomechanical model in a direction which is defined based on the orientation of the mobile device. A deformed model may be displayed on a display of the mobile device. The system and the method provide an intuitive way of simulating the breast deformation.