liposomal formulation, pharmaceutical composition, use of a liposomal formulation, method for treating cancer, and, process for preparing a liposomal formulation
ELBA PINTO DA SILVA BOM,JONAS PERALES,LUCIANA FACCHINETTI DE CASTRO GIRÃO,MANUELA COLLA CARVALHEIRO,MARIA ANTONIETA FERRARA,MARIA BÁRBARA DOS ANJOS FIGUEIRA MARTINS,MARIA LUÍSA TEIXEIRA DE AZEVEDO COR
申请号：
BR102018069598
公开号：
BR102018069598A2
申请日:
2018.09.25
申请国别(地区):
BR
年份:
2020
代理人:
摘要：
the present invention relates to liposomal formulations comprising enzymes with asparaginase activity covalently attached to the ends of polyethylene glycol molecules exposed on the surface of liposomes. the liposomal formulations described herein are useful in the treatment of cancer, particularly leukemias.a presente invenção refere-se a formulações lipossomais compreendendo enzimas com atividade asparaginase ligadas covalentemente às extremidades de moléculas de polietileno glicol expostas na superfície de lipossomos. as formulações lipossomais aqui descritas são úteis no tratamento de câncer, particularmente leucemias.
