A multi-position biopsy guide system and a method of using such biopsy guide system is proposed. The biopsy guide system comprises a 2D matrix ultra-sound transducer (3) and comprises at least one biopsy needle guide (5) adapted for guiding a biopsy needle along a biopsy path (7). Therein, the multi-position biopsy guide system is adapted to controllably guide the biopsy needle along biopsy paths at variable locations with respect to the 2D matrix ultrasound transducer. Preferably, a location of the biopsy needle guide (5) with respect to the matrix ultrasound transducer may be determined and an ultrasound image in an image plane aligned with a biopsy path corresponding to the determined location of the biopsy needle guide may be acquired. Thereby, a biopsy process may be monitored for various locations and orientations of a guided biopsy needle.
