PROBLEM TO BE SOLVED: To provide a pharmaceutical composition useful as a therapeutic and/or preventive agent of a respiratory disease such as asthma, the pharmaceutical composition to be administered in combined with another medicine such as a phosphodiesterase 4 inhibitor.SOLUTION: The present invention provides a pharmaceutical composition containing a substituted biaryl compound represented by formula (I), or a pharmacologically acceptable salt thereof [R1 is a carboxyl group, which may be protected W is nitrogen or a -CH= group R2 is an ethoxy group, a 1-propenyl group or a 1-propynyl group Z is a phenyl group, a 3-fluorophenyl group, a pyridine-2-yl group, a pyridine-3-yl group, a thiophene-2-yl group, or a thiophene-3-yl group].SELECTED DRAWING: NoneCOPYRIGHT: (C)2018,JPO&INPIT【課題】喘息等の呼吸器疾患に対する治療薬及び/又は予防薬として有用な医薬組成物であって、ホスホジエステラーゼ4阻害薬等の他の医薬と組み合わせて投与される医薬組成物の提供。【解決手段】式(I)に示される置換ビアリール化合物、又はその薬理上許容される塩を含む医薬組成物。[R1は保護されていてもよいカルボキシル基;Wは窒素又は-CH=基;R2はエトキシ基、1-プロペニル基又は1-プロピニル基;Zはフェニル基、3-フルオロフェニル基、ピリジン-2-イル基、ピリジン-3-イル基、チオフェン-2-イル基、又はチオフェン-3-イル基]【選択図】なし
