Andrew Lynn,William Bonfield,Zachary D. Wissner-Gross,Brendan A. Harley,Ioannis V. Yannas,Lorna J. Gibson
申请号：
US12377221
公开号：
US08318902B2
申请日:
2007.08.10
申请国别(地区):
US
年份:
2012
代理人:
摘要：
A process for the preparation of a composite biomaterial comprising: providing a first substantially solid component comprising one or more of collagen, a glycosaminoglycan, albumin, hyaluronan, chitosan, and synthetic polypeptides comprising a portion of the polypeptide sequence of collagen, and optionally an inorganic material, said component having at least a surface portion that is porous providing a fluid composition comprising one or more of collagen, a glycosaminoglycan, albumin, hyaluronan, chitosan, and synthetic polypeptides comprising a portion of the polypeptide sequence of collagen, and a liquid carrier, and optionally an inorganic material contacting said fluid composition with said porous surface portion of said first component cooling said fluid composition to a temperature at which the liquid carrier transforms into a plurality of solid crystals or particles removing at least some of the plurality of solid crystals or particles by sublimation and/or evaporation.
