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MODULATEURS DU RECEPTEUR D'HYDROCARBURE ARYLE ET UTILISATIONS ASSOCIEES
专利权人:
BETH ISRAEL DEACONESS MEDICAL CENTER; INC.
发明人:
CHAIKOF, ELLIOT,SUN, LIJUN
申请号:
CA3095934
公开号:
CA3095934A1
申请日:
2019.04.05
申请国别(地区):
CA
年份:
2019
代理人:
摘要:
Provided are compounds of Formula (I), and pharmaceutically acceptable salts, solvates, hydrates, stereoisomers, tautomers, isotopically labeled derivatives, polymorphs, and prodrugs thereof, wherein X1-X4, RX, RC, RB, n, and Ring A are as defined herein. The compounds may be aryl hydrocarbon receptor agonists or partial aryl hydrocarbon receptor agonists. Also provided are pharmaceutical compositions comprising a compound of Formula (I) and methods of using such compounds for treating diseases and conditions related to the activity of an aryl hydrocarbon receptor, such as, for example, inflammatory diseases, autoimmune diseases, metabolic disorders, and proliferative diseases.
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