TRUSTEES OF BOSTON UNIVERSITY;NORTHEASTERN UNIVERSITY;BOSTON MEDICAL CENTER CORPORATION
发明人:
SHERR, DAVID H.,POLLASTRI, MICHAEL,SCHLEZINGER, JENNIFER,HAIGH MOLINA, SARAH,SCHAUS, SCOTT,GIGUERE, JOSHUA ROBERT
申请号：
CA2807199
公开号：
CA2807199A1
申请日:
2011.07.27
申请国别(地区):
CA
年份:
2012
代理人:
摘要：
Provided herein are novel agents that modulate AhR activity for use in therapeutic compositions and methods thereof for inhibiting cancer cell proliferation and tumor cell invasion and metastasis. The agents comprise AhR inhibitors or non-constitutive AhR agonists of Formula (I) and (II) for the inhibition of cancer cell growth and parameters that characterize tumor metastasis, such as tumor cell invasiveness.
