Described herein are methods and compositions relating to the treatment of e.g., cancer, autoimmune disease, immune deficiency, and/or neurodegenerative disease. In some embodiments, the methods of treatment relate to administering a compound as described herein. In some embodiments, the subject treated according to the methods described herein is a subject determined to have an increased level of DNA damage.本文描述關於治療例如癌症、自體免疫疾病、免疫缺乏症及/或神經退化性疾病的方法及組合物。在一些實施例中，治療方法係關於投與如本文所述的化合物。在一些實施例中，根據本文所述方法治療的個體為經確定具有升高之DNA損傷程度的個體。
