The present invention relates to the improvement of miRNA inhibitors (synthetic thaw decoy, s-tud).The invention is a miRNA inhibitory complex containing RNA or its analogues, wherein the miRNA inhibitory complex comprises at least one double stranded structure and a miRNA binding sequence, wherein two chains of the miRNA binding sequence have the double stranded structure At least one end of each strand is coupled to one strand, and the miRNA inhibition complex provides a miRNA inhibition complex containing at least one cross-linked nucleic acid.本発明は、miRNA阻害剤(合成Tough Decoy, S-TuD)の改良に関する。本発明は、RNAまたはその類縁体を含むmiRNA阻害複合体であって、該miRNA阻害複合体は、少なくとも1つの二本鎖構造およびmiRNA結合配列を含み、該miRNA結合配列の2つの鎖が、該二本鎖構造の少なくとも片端の2つの鎖に一本ずつ結合しており、該miRNA阻害複合体は少なくとも1つの架橋核酸を含む、miRNA阻害複合体を提供する。
