Polyamine transporter selective compounds as anti-cancer agents

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专利权人:

Otto Phanstiel; IV

发明人:

Otto Phanstiel, IV,Navneet Kaur

申请号：

US12113540

公开号：

US08497398B1

申请日:

2008.05.01

申请国别(地区):

US

年份:

2013

代理人:

摘要：

Several aromatic hydrocarbons di-substituted with a polyamine are described according to formulas selected from compounds 4, 7, 10, 15 and pharmaceutically acceptable salts thereof. The novel dimeric polyamines of the present invention demonstrate enhanced penetration into cells having an upregulated polyamine transport system, such as various types of cancer cells. The disclosed aromatic polyamine dimers provide highly efficient drugs for targeting cancer cells with active polyamine transporters.

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