YU, Kyung A,YOON, Ji Sung,EOM, Deok Ki,LEE, Yeon Im,SHIN, Hye Ryun,LEE, Jun Hee,SEO, Ha Nee,KIM, Ji Duck,LEE, Sang Ho,LEE, Chun Ho
申请号：
ES14850178
公开号：
ES2667276T3
申请日:
2014.10.02
申请国别(地区):
ES
年份:
2018
代理人:
摘要：
A compound represented by Chemical Formula 1 below or a pharmaceutically acceptable salt thereof: ** Formula ** wherein, X is a bond, -CH2-, -O-, -NH-, -N (CH3) - or -N (CHO) -, X1, X2 and X3 are each independently CH or N, R1 is phenyl, pyrazolyl, pyridinyl, pyrimidinyl, quinolinyl, or phenyl condensed with a 6-membered heterocycloalkyl that includes one or two nitrogen atoms or oxygen, wherein R1 is unsubstituted or substituted with one to five substituents independently selected from the group consisting of C1-6 alkyl, C1-4 alkoxy, C1-4 haloalkyl, C1-4 haloalkoxy, hydroxy, nitro, cyano, halogen, amino, phenyl, phenoxy, halogen substituted phenoxy, -COO (C1-4 alkyl) and -NHCO (C1-4 alkyl), R2 is naphthyl, phenyl or pyridinyl, wherein R2 is unsubstituted or substituted with one to three substituents independently selected from the group consisting of C1-6 alkyl, C1-4 alkoxy, C1-4 haloalkyl, C1 haloalkoxy -4, cyano, halogen and phenyl, R3 is -CH2NR4R5, -CONR4R5, -COOR4 or -NR4R5, where R4 and R5 are each independently hydrogen or C1-4 alkyl, R4 and R5 together with the atom of Nitrogen to which R4 and R5 are attached form a 5-membered or 6-membered heterocyclyl nitrogen.Un compuesto representado por la Fórmula Química 1 a continuación o una sal farmacéuticamente aceptable del mismo:**Fórmula** en donde, X es un enlace, -CH2-, -O-, -NH-, -N(CH3)- o -N(CHO)-, X1, X2 y X3 son cada uno independientemente CH o N, R1 es fenilo, pirazolilo, piridinilo, pirimidinilo, quinolinilo, o fenilo condensado con un heterocicloalquilo de 6 miembros que incluye uno o dos átomos de nitrógeno u oxígeno, en donde el R1 está sin sustituir o sustituido con uno a cinco sustituyentes seleccionados independientemente entre el grupo que consiste en alquilo C1-6, alcoxi C1-4, haloalquilo C1-4, haloalcoxi C1-4, hidroxi, nitro, ciano, halógeno, amino, fenilo, fenoxi, fenoxi sustituido con halógeno, -COO(alquilo C1-4) y -NHCO(alquilo C1-4), R2 es naftilo, fenilo o piridinilo, en donde el R2 está s
