#$%^&*AU2013203794A120130502.pdf#####ABSTRACT: The present invention provides methods for treating constipation-predominant irritable bowel syndrome comprising administering to a patient in need thereof, a polymeric proanthocyanidin composition from a Croton species or Calophyllum species in an amount 5 sufficient to treat constipation-predominant irritable bowel syndrome (c-IBS). Treatment of cIBS includes the treatment of the constipation component of c-IBS as well as the pain and abdominal discomfort associated with c-IBS. In one embodiment, the polymeric proanthocyanidin compound is crofelemer. The present invention in an alternative embodiment also provides methods for treating alternating constipation-predominant/diarrhea-predominant 10 irritable bowel syndrome.
