A method for selecting a device adapted to treat disordered breathing in a patient with one or more comorbid diseases is provided. More particularly, a method for reducing a potential group of patient interface devices adapted to treat disordered breathing of a patient to an optimized group, includes: prescreening the patient； determining a measure of a comorbidity of the patient from the prescreening； comparing the measure of the comorbidity to a corresponding predetermined threshold； and determining the optimized group from the potential group. The optimized group may include a reduced number of devices from which a particular device is then selected or may include only a single particular device.
