Active PKR compounds for the treatment of diseases and disorders associated with PKR and/or PKM2. Claim 1: A formula compound (1),Or a drug-acceptable saltThere, it's a link.- (Cr.8309；), 834848； -,- 83099 (Cr.8309； - R83090909')； 8348； - U-O-；Each R1,R1',R and R'are independent H.- Apartment No. 83318326, C832183,- Alquenilo C83228331-832626；- Asphalt C83228331832626；- Cyoquilo C83223 degrees 83318328；Cyoquenio C83248C83318328；cumeneArilo,HeterosexualsHalogen.- um.- Or83099,- SR83099；- No. 8322；- No. 8309； No. 83099 "；- S(O) 8322； (R83099,- S (O) 8322； - 8309； - R83099'；- S(o) R83099,- S (O) 8309； R8309'；- 8309；]- 8309； s (o) R8309'；- C(O) R8309O-C(O) Or83099；Every man JackAlquenilo,Blue Nile StateBicycle.Ring nailcumeneArilo or heterosexual alternatives can be replaced by one or more alternatives selected from the Oxo class.Halogen.- um.- R83099,- Or83099,- SR83099；- No. 8322；- No. 8309； No. 83099 "；- S(O) 8322； (R83099,- S (O) 8322； - 8309； - R83099'；- S(o) R83099,- S (O) 8309； R8309'；- 8309；]- 8309； s (o) R8309'；- C(O) R8309Y-C(O) Or83099；Or R1 and R1',Or R and R',Together with the atoms they come into contact with,It can be combined into a C832323833183288A ring.HeterosexualitySpirulina spp. E. C8325C83318328E or 5 to 8 members；Or R1 and R2,Together with the atoms they come into contact with,A. Can be merged into one to eight members；R3 is independent - H,- Apartment No. 83318326, C832183,- Alquenilo C83228331-832626；- Asphalt C83228331832626；- Cyoquilo C83223 degrees 83318328；- Cyclolquenilo C832483318328；cumeneArilo,Heterosexuals- S(O) 8322； (R83099,- S (O) 8322； - 8309； - R83099'；- S(o) R83099,- S (O) 8309； R8309'；- C(O) R8309O-C(O) Or83099；Every man JackAlquenilo,Blue Nile StateBicycle.Ring nailcumeneArilo or heterosexual alternatives can be replaced by one or more alternatives selected from the Oxo class.Halogen.- um.- R83099,- Or83099,- SR83099；- No. 8322；- No. 8309； No. 83099 "；- S(O) 8322； (R83099,- S (O) 8322； - 8309； - R83099'；- S(o) R83099,- S (O) 83
