A compound made from a derivative of cyclopentadiene (I),WHERE A1 IS ABSENT OR OXYGEN, CH2O, CH2, CARBONYL, CONR11； R1 IS H, CARBOXY, MORPHOLINYL, PIPERIDINYL, AMONG OTHERS； R2 IS H； R3 and R4 ARE H, C1-C8 ALKYL, PHENYL； R5 IS C1-C8 ALKYL, PHENYL, NAPHTHYL, AMONG OTHERS； R11 IS H OR C1-C8 ALKYL. THEY ARE PREFERRED COMPOUNDS: CYANOMETHYL-AMIDE ACID (1R, 2R, 4R) -4-BENZENOSULFONYL-2- (MORPHOLINE-4-CARBONYL) -CYCLOPENTANOCARBOXYLIC, (1-CIANO-CICLOPROPIL) -AMID ACID (1R, 2R ) -4-BENZENOSULFONYL-2- (MORPHOLINE-4-CARBONYL) -CYCLOPENTANOCARBOXYLIC, CYANOMETHYL-AMIDE ACID (1R, 2R, 4R) -4- (2-CHLORINE-BENZENE-SULPHONYL) -2- (MORPHOLINE-4- CARBONIL) -CYCLOPENTANOCARBOXILICO,There are others A preparation procedure and a drug synthesis were also mentioned. These compounds are inhibitors of velvet protein S or L, and are effective tools for the treatment of diabetes, carcinogenicity, diabetes nefropatia, etc.REFERIDA A UN COMPUESTO DERIVADO DE CICLOPENTANO DE FORMULA (I), DONDE A1 ESTA AUSENTE O ES OXIGENO, CH2O, CH2, CARBONILO, CONR11； R1 ES H, CARBOXI, MORFOLINILO, PIPERIDINILO, ENTRE OTROS； R2 ES H； R3 Y R4 SON H, ALQUILO C1-C8, FENILO； R5 ES ALQUILO C1-C8, FENILO, NAFTILO, ENTRE OTROS； R11 ES H O ALQUILO C1-C8. SON COMPUESTOS PREFERIDOS: CIANOMETIL-AMIDA DEL ACIDO (1R,2R,4R)-4-BENCENOSULFONIL-2-(MORFOLINA-4-CARBONIL)-CICLOPENTANOCARBOXILICO, (1-CIANO-CICLOPROPIL)-AMIDA DEL ACIDO (1R,2R,4R)-4-BENCENOSULFONIL-2-(MORFOLINA-4-CARBONIL)-CICLOPENTANOCARBOXILICO, CIANOMETIL-AMIDA DEL ACIDO (1R,2R,4R)-4-(2-CLORO-BENCENO-SULFONIL)-2-(MORFOLINA-4-CARBONIL)-CICLOPENTANOCARBOXILICO, ENTRE OTROS. TAMBIEN ESTA REFERIDA A UN PROCEDIMIENTO DE PREPARACION Y A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS SON INHIBIDORES DE LA CISTEINA-PROTEASA CATEPSINA S O L Y SON UTILES EN EL TRATAMIENTO DE LA DIABETES, ATEROSCLEROSIS, NEFROPATIA DIABETICA, ENTRE OTRAS
