Seung Poon Kwak;Pamela Kelley;Menelas N. Pangalos;Lioudmila Tchistiakova;William Kelley, legal representative;David S. Howland;Frank S. Walsh;Margaret M. Zaleska;Riyez Karim;Xiang-Yang Tan
发明人:
Frank S. Walsh,Margaret M. Zaleska,David S. Howland,Lioudmila Tchistiakova,Riyez Karim,Pamela Kelley,Xiang-Yang Tan,Seung Poon Kwak,Menelas N. Pangalos
申请号：
US13030978
公开号：
US08349327B2
申请日:
2011.02.18
申请国别(地区):
US
年份:
2013
代理人:
摘要：
The disclosure provides novel molecules related to growth and differentiation factor-8 (GDF-8), in particular mouse and humanized antibodies, and antibody fragments, including those that inhibit GDF-8 activity and signaling in vitro and/or in vivo. The disclosure also provides methods for diagnosing, treating, ameliorating, preventing, prognosing, or monitoring degenerative orders of muscle, bone, and insulin metabolism, etc., in particular amyotrophic lateral sclerosis (ALS). In addition, the disclosure provides pharmaceutical compositions for the treatment of such disorders by using the antibodies, polypeptides, polynucleotides, and vectors of the invention.
