Kam Wai Wong,Yuen Kwan Law,Thomas Efferth,Onat Kadioglu,Liang Liu
申请号：
US14953860
公开号：
US09974766B2
申请日:
2015.11.30
申请国别(地区):
US
年份:
2018
代理人:
摘要：
Prenylated isoflavones are suitable to specifically inhibit P-glycoprotein in multidrug-resistant cancer cells leading to an accumulation of cytotoxic compounds or therapeutic compounds in the cells while having exceptionally increased cytotoxic activity specifically towards multidrug-resistant cancer cells and while allowing for an increased activity of chemotherapeutic compounds towards which the cells are resistant.Also in accordance with the present invention is a method for specifically targeting cancer cells with multidrug-resistance as well as a method of potentiating the activity of a chemotherapeutic compound in multidrug-resistant cancer cells. In a further aspect, a kit including a prenylated isoflavone and a chemotherapeutic compound is provided.
