PROBLEM TO BE SOLVED: To provide a new and excellent therapeutic and/or preventive method for prostate cancer and the like based on selective inhibitory action on the 17&betaHSD type 5.SOLUTION: It has been found that {1-[(indol-2-yl)carbonyl]piperidyl}alkanol derivative has strong selective inhibitory action on the 17&betaHSD type 5 and is able to be used as a therapeutic and/or preventive agent for diseases such as prostate cancer associated with the 17&betaHSD type 5 without accompanied with adverse effects caused by teststerone reduction.COPYRIGHT: (C)2011,JPO&INPIT【課題】17βHSDtype5の選択的阻害作用に基づく前立腺癌等の新規かつ優れた治療及び/又は予防方法を提供する。【解決手段】{1-[(インドール-2-イル)カルボニル]ピペリジル}アルカノール誘導体が強力な17βHSDtype5選択的阻害活性を有すること、及び、テストステロン減少による副作用を伴わない、前立腺癌等の17βHSDtype5の関与する疾患の治療剤及び/又は予防剤として使用しうることを知見して本発明を完成した。【選択図】なし
