Use of antrodan for preparing cancer therapeutic pharmaceutical composition and inhibiting side effects of chemotherapeutic drugs capable of inhibiting the growth of cancer as well as the cancer metastasis
The invention relates to a use of an antrodia cinnamomea mycelium glycoprotein (antrodan) for preparing a cancer therapeutic pharmaceutical composition and also providing an effect of inhibiting side effects of chemotherapeutic drugs. The antrodan inhibits the growth of cancer by increasing an interferon-, and also inhibits the cancer metastasis via reducing an interleukin 6 (IL-6) expression, and further via reducing a mitogen-activated protein kinase (MAPK) phosphorylation, reducing a signal transducer and activator of transcription 3 (STAT3) phosphorylation, a matrix metalloproteinases (MMPs)-2 expression or matrix metalloproteinases (MMPs)-9 expression.本發明係一種牛樟芝菌絲體醣蛋白安綽醣用於製備癌症治療醫藥組合物,同時具有抑制化療藥物副作用之用途;安綽醣經由提高干擾素-γ抑制癌症生長,並可經由降低介白素-6(interleukin 6,IL-6)表現而進一步由降低有絲分裂原活化蛋白激酶(mitogen-activated protein kinase,MAPK)磷酸化、降低信號及轉錄激活蛋白3(signal transducer and activator of transcription 3,STAT3)磷酸化、基質金屬蛋白酶(matrix metalloproteinases,MMPs)-2表現或基質金屬蛋白酶(matrix metalloproteinases,MMPs)-9表現而抑制癌症轉移。
