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CRISTAUX D'UN DÉRIVÉ DE QUINAZOLINE ET LEUR PROCÉDÉ DE PRÉPARATION
专利权人:
Xuanzhu Pharma Co.; Ltd.
发明人:
SHU, Chutian,WANG, Jinyuan,WANG, Zhenhua
申请号:
EP16877795
公开号:
EP3395810A4
申请日:
2016.12.23
申请国别(地区):
EP
年份:
2019
代理人:
摘要:
The invention relates to Crystal form I and Crystal form II of dihydrochloride of N-(4-((3-chloro-4-fluorophenyl)amino)-7-((7-methyl-7-azaspiro[3.5]nonan-2-yl)methoxy)quinazoli n-6-yl)acrylamide represented by the following Formula (I), and preparation methods therefor, wherein the Crystal form I has an X-ray powder diffraction pattern having characteristic peaks at the 2 ¸ positions of 6.0±0.2°, 7.3±0.2°, 11.7±0.2°, 12.9±0.2°, 18.4±0.2°, 24.7±0.2°, and 26.3±0.2°, as determined by using Cu-K± radiation, and the Crystal form II has an X-ray powder diffraction pattern having characteristic peaks at the 2 ¸ positions of 5.0±0.2°, 7.0±0.2°, 10.1±0.2°, 17.0±0.2°, 26.0±0.2°, and 26.5±0.2°, as determined by using Cu-K± radiation.
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中国工程科技知识中心
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http://www.ckcest.cn/home/

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