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喹唑啉衍生物的晶體及其製備方法
专利权人:
XUANZHU PHARMA CO.,LTD.;山東軒竹醫藥科技有限公司
发明人:
舒楚天,王金遠,王振華
申请号:
HK18115948
公开号:
HK1256860A1
申请日:
2018.12.12
申请国别(地区):
HK
年份:
2019
代理人:
摘要:
The invention relates to Crystal form I and Crystal form II of dihydrochloride of N-(4-((3-chloro-4-fluorophenyl)amino)-7-((7-methyl-7-azaspiro[3.5]nonan-2-yl)methoxy)quinazoli n-6-yl)acrylamide represented by the following Formula (I), and preparation methods therefor, wherein the Crystal form I has an X-ray powder diffraction pattern having characteristic peaks at the 2 ¸ positions of 6.0±0.2°, 7.3±0.2°, 11.7±0.2°, 12.9±0.2°, 18.4±0.2°, 24.7±0.2°, and 26.3±0.2°, as determined by using Cu-K± radiation, and the Crystal form II has an X-ray powder diffraction pattern having characteristic peaks at the 2 ¸ positions of 5.0±0.2°, 7.0±0.2°, 10.1±0.2°, 17.0±0.2°, 26.0±0.2°, and 26.5±0.2°, as determined by using Cu-K± radiation.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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