The present invention relates to new, highly efficient synergistic compositions comprising mixtures of organic acids in combination with specific detergents or emulgators. That is, applied as an adjuvant or additive, said mixtures significantly increase the efficacy and biocompatibility of conventional herbicide products. The new synergistic composition thereby allows significant reduction of active ingredients of conventional herbicide agents. The higher efficacy of the synergistic mixture also allows to address the elimination of herbicide-resistant or herbicide-tolerant plants.