As for this invention, the arutemishinin derivative which has the structure which is shown in the below-mentioned structural formula I, the manufacturing methodIt regards the medicine composition and the use which include use and the particular arutemishinin derivative. The medicine composition which includes the arutemishinin derivative and the particular arutemishinin derivative which relate to this invention is immunity control action, can be used more safely. It possesses the production and practical value which as for the medicine composition which includes the particular arutemishinin derivative the tablet and the circular medicine etc being convenient, it is possible, is wide to manufacture in active medicine shape over long term.本発明は、下記の構造式Iに示された構造を持つアルテミシニン誘導体、その調製方法、用途及び当該アルテミシニン誘導体を含む薬物組成物と用途に関する。本発明に係るアルテミシニン誘導体及び当該アルテミシニン誘導体を含む薬物組成物は、免疫抑制作用があり、より安全に使用されることができる。当該アルテミシニン誘導体を含む薬物組成物は錠剤、丸剤など便利で長期に渡って使用可能な剤形に調製することができ、幅広い生産と実用価値を有する。