James Philip O'Connell,John Robert Porter,Alastair Lawson,Boris Kroeplien,Stephen Edward Rapecki,Timothy John Norman,Graham John Warrellow
申请号：
US15736520
公开号：
US10705094B2
申请日:
2015.10.22
申请国别(地区):
US
年份:
2020
代理人:
摘要：
It has been demonstrated that certain compounds bind to TNF and stabilise a conformation of trimeric TNF that binds to the TNF receptor. Accordingly, these compounds can be used as modulators of TNF. A new assay for identifying compounds with this mechanism of action is also disclosed.
