O'CONNELL, JAMES PHILIP,PORTER, JOHN ROBERT,LAWSON, ALASTAIR,ARAKAKI, TRACY LYNN,LIGHTWOOD, DANIEL JOHN,WOOTTON, REBECCA JAYNE,OCONNELL, JAMES PHILIP
申请号：
CA2988723
公开号：
CA2988723A1
申请日:
2015.10.22
申请国别(地区):
CA
年份:
2016
代理人:
摘要：
It has been demonstrated that certain compounds bind to TNF and stabilise a conformation of trimeric TNF that binds to the TNF receptor. Antibodies which selectively bind to complexes of such compounds with TNF superfamily members are disclosed. These antibodies may be used to detect further compounds with the same activity, and as target engagement biomarker.
