Juliana Megan WODA,Wouter VAN'T HOF,Wouter VANT HOF
申请号：
US14051164
公开号：
US20140037596A1
申请日:
2013.10.10
申请国别(地区):
US
年份:
2014
代理人:
摘要：
The invention is generally directed to reducing inflammation by means of cells that secrete factors that reduce leukocyte extravasation. Specifically, the invention is directed to methods using cells that secrete factors that downregulate the expression of cellular adhesion molecules in vascular endothelial cells. Downregulating expression of cellular adhesion molecules reduces leukocyte adhesion to the endothelial cells such that extravasation is reduced. The end result is a reduction of inflammation. The cells are non-embryonic non-germ cells that have pluripotent characteristics. These may include expression of pluripotential markers and broad differentiation potential.
