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РЕКОМБИНАНТНЫЕ БЕЛКИ И ИХ ПРИМЕНЕНИЯ В ТЕРАПЕВТИЧЕСКИХ ЦЕЛЯХ
专利权人:
БИОВЕН 3 ЛИМИТЕД (BM)
发明人:
ЧАРЛЬТОН Кит Алан (GB),Д"ОНДТ Эрик (BE)
申请号:
RU2014124923/10
公开号:
RU2014124923A
申请日:
2012.11.21
申请国别(地区):
RU
年份:
2015
代理人:
摘要:
1. Recombinant protein soderzhaschiyimmunogennuyu polypeptide sequence and, together with said polypeptide sequence a sequence comprising at least part rosta.2 factor. Recombinant protein according to Claim. 1, wherein said immunogenic polypeptide comprises a sequence of a protein, cholera toxin B (CT-B) .3. Recombinant protein according to Claim. 1, wherein said growth factor comprises epidermal growth factor (EGF) .4. Recombinant protein according to Claim. 1, wherein at least said portion of said growth factor includes neutralizing domain rosta.5 factor. Recombinant protein according to Claim. 1, wherein at least said portion of said growth factor includes one or more of the following growth factors, full length or portions thereof selected from the group consisting of IGF-1, IGF-2, FGF1, FGF2, TGF -a, TGF-13, VEGF-A, VEGF-B, VEGF-C, VEGF-D, PDGF, NGF, EGF, HGF, BMP, and IL 1-6.6. Recombinant protein according to Claim. 1, wherein at least said portion of said growth factor comprises at least two different full-length growth factor neutralizing or domains present in said artificial belke.7. Recombinant protein according to Claim. 1, wherein at least said portion of said growth factor comprises a protein indicated as a separate domain, or as two or more tandem repeats of one or more growth factors or their full length neutralizing domeny.8. Recombinant protein according to Claim. 1, wherein at least said portion of said growth factor neutralizing domain or segregated from the rest of the fusion protein via peptide "spacer" 9. Recombinant protein according to claim. 8, wherein said peptide is1. Рекомбинантный белок, содержащийиммуногенную последовательность полипептида и,вместе с указанной последовательностью полипептида, последовательность, содержащую по меньшей мере часть фактора роста.2. Рекомбинантный белок по п. 1, где указанная иммуногенная последовательность полипептида включает в себя белковый холерный токсин B (CT-B).3. Рекомбинантный белок по п. 1, где ук
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