PARK, Bong Hyun,박봉현,CHO, Jung Hyun,조정현,KIM, Young Hun,김영훈,KIM, Yong Il,김용일
申请号：
KRKR2018/002889
公开号：
WO2018/182205A1
申请日:
2018.03.12
申请国别(地区):
KR
年份:
2018
代理人:
摘要：
The present invention relates to a stabilized pharmaceutical composition containing bazedoxifene acetate as an active ingredient and an antioxidant. Specifically, the present invention provides a pharmaceutical composition, which suppresses the production of related substances and has improved long-term storage stability by comprising an antioxidant or a coating base in addition to bazedoxifene acetate, which remarkably increases the production of related substances in oxidative conditions.La présente invention concerne une composition pharmaceutique stabilisée contenant de l'acétate de bazedoxifène en tant que principe actif et un antioxydant. De façon spécifique, la présente invention concerne une composition pharmaceutique, qui supprime la production de substances apparentées et a une stabilité de stockage à long terme améliorée en comprenant un antioxydant ou une base de revêtement en plus de l'acétate de bazedoxifène, ce qui augmente remarquablement la production de substances apparentées dans des conditions oxydatives.본 발명은 활성성분으로 바제독시펜 아세테이트 및 항산화제를 포함하는 안정화된 약제학적 조성물에 관한 것이다. 구체적으로, 산화 조건으로 유연물질의 생성이 현저히 증가하는 바제독시펜 아세테이트에 항산화제 또는 코팅기제를 포함하여 유연물질의 생성을 억제하고 장기간 보관안정성이 개선된 약제학적 조성물을 제공한다.
