177lutetium-labeled bombesin analogs for radiotherapy

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专利权人:

PIRAMAL IMAGING SA;UNIVERSITÄTSSPITAL BASEL

发明人:

BORKOWSKI SANDRA,MANSI ROSALBA,MÄCKE HELMUT

申请号：

NZ61074011

公开号：

NZ610740A

申请日:

2011.11.21

申请国别(地区):

NZ

年份:

2015

代理人:

摘要：

Disclosed is a use of a conjugate of Formula I [177Lu] - R1 - R2 - R3 (I) wherein R1 is a metal chelator suitable for chelating [177Lu], R2 is a spacer linked to N-terminal of R3 or a covalent bond, R3 is a bombesin analog peptide antagonist of sequence from seq 1 to 4, Seq 1: D-Phe-Gln-Trp-Ala-Val-Gly-His-Sta-Leu-NH2； Seq 2: D-Phe-Gln-Trp-Ala-Val-Gly-His-LeuѰ (CHOH-CH2)-(CH2) 2-CH3； Seq 3: D-Phe-Gln-Trp-Ala-Val-Gly-His-LeuѰ(CH2NH)-Phe-NH2； and Seq 4: D-Phe-Gln-Trp-Ala-Val-Gly-His-LeuѰ (CH2NH)-Cys-NH2. and pharmaceutically acceptable salts thereof, in the manufacture of a medicament for the treatment of tumors.

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