RENSSELAER POLYTECHNIC INSTITUTE;BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA;THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL
发明人:
Jian Liu,Yongmei Xu,Robert J. Linhardt,Edward Harris
申请号：
US14898865
公开号：
US20160122446A1
申请日:
2014.06.17
申请国别(地区):
US
年份:
2016
代理人:
摘要：
Methods and systems for synthesizing heparin compounds are provided. The chemoenzymatic synthesis of structurally homogeneous low molecular weight heparins that have a reversible anticoagulant activity is provided. Also disclosed are heparin compounds having anticoagulant activity, including a binding affinity to antithrombin and an anti-Xa activity, but no detectable anti-lla activity. Additionally, provided are synthetic, low-molecular weight heparin compounds with reversible anticoagulant activity, where the anticoagulant activity is reversible by protamine.
