Rensselaer Polytechnic Institute;The Board of Regents of the University of Nebraska;The University of North Carolina at Chapel Hill
发明人:
申请号：
EP14812890.3
公开号：
EP3011043A4
申请日:
2014.06.17
申请国别(地区):
EP
年份:
2017
代理人:
摘要：
Methods and systems for synthesizing heparin compounds are provided. The chemoenzymatic synthesis of structurally homogeneous low molecular weight heparins that have a reversible anticoagulant activity is provided. Also disclosed are heparin compounds having anticoagulant activity, including a binding affinity to antithrombin and an anti-Xa activity, but no detectable anti-lla activity. Additionally, provided are synthetic, low-molecular weight heparin compounds with reversible anticoagulant activity, where the anticoagulant activity is reversible by protamine.
