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Piperazines as anti-malaria agents
专利权人:
ACTELION PHARMACEUTICALS LTD.
发明人:
AISSAOUI, HAMED,BOSS, CHRISTOPH,CORMINBOEUF, OLIVIER,HEIDMANN, BIBIA,SIEGRIST, ROMAIN
申请号:
ES11702702
公开号:
ES2523739T3
申请日:
2011.01.04
申请国别(地区):
ES
年份:
2014
代理人:
摘要:
A compound of formula I: Formula I ** Formula ** in which - X is CH or N; R1 represents -NO2, -N (CH3) 2, or -NCH3 (CH2CH2OH); and R2 represents hydrogen, methyl, ethyl, n-propyl, isopropyl, tert-butyl, cyano, halogen, methoxy, ethoxy, n-propoxy, isopropoxy, trifluoromethyl, difluoromethoxy, methylsulfonyl, acetyl, or acetylamino; or - X is CH, R1 is hydrogen, and R2 is ethyl, isopropyl, tert-butyl, ethoxy, n-propoxy, isopropoxy, methylsulfonyl, acetylamino, or methoxycarbonyl; or - X is CH, R1 is cyano, and R2 is ethyl, isopropyl, tert-15-butyl, ethoxy, n-propoxy, isopropoxy, trifluoromethyl, difluoromethoxy, trifluoromethoxy, methylsulfonyl, or acetylamino; or - X is CH, R1 is chloro, and R2 is ethyl, isopropyl, tert-butyl, ethoxy, n-propoxy, isopropoxy, difluoromethoxy, methylsulfonyl, or acetylamino; or - X is CH, R1 is methoxy or isopropoxyl, and R2 is trifluoromethyl; or - X is CH, R1 is methylsulfonyl or ethylsulfonyl, and R2 is trifluoromethyl, ethyl, isopropyl, tert-butyl, ethoxy, n-propoxy, isopropoxy, or difluoromethoxy; or a salt of such a compound.Un compuesto de fórmula I: Fórmula I **Fórmula** en la cual - X es CH o N; R1 representa -NO2, -N(CH3)2, o -NCH3(CH2CH2OH); y R2 representa hidrógeno, metilo, etilo, n-propilo, isopropilo, tert-butilo, ciano, halógeno, metoxilo, etoxilo, n-propoxilo, isopropoxilo, trifluorometilo, difluorometoxilo, metilsulfonilo, acetilo, o acetilamino; o - X es CH, R1 es hidrógeno, y R2 es etilo, isopropilo, tert-butilo, etoxilo, n-propoxilo, isopropoxilo, metilsulfonilo, acetilamino, o metoxicarbonilo; o - X es CH, R1 es ciano, y R2 es etilo, isopropilo, tert-15 butilo, etoxilo, n-propoxilo, isopropoxilo, trifluorometilo, difluorometoxilo, trifluorometoxilo, metilsulfonilo, o acetilamino; o - X es CH, R1 es cloro, y R2 es etilo, isopropilo, tert-butilo, etoxilo, n-propoxilo, isopropoxilo, difluorometoxilo, metilsulfonilo, o acetilamino; o - X es CH, R1 es metoxilo o isopropoxilo, y R2 es trifluorometilo; o - X es CH, R1 es
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