Herein is reported a lipid particle comprising an apolipoprotein, a phosphatidylcholine and a lipid, such as a phospholipid, fatty acid or steroid lipid. In one embodiment the lipid particle comprises only one apolipoprotein. In one embodiment the lipid particle is consisting of one apolipoprotein, a phospholipid, a lipid, and a detergent. In one embodiment the lipid is a second phosphatidylcholine, wherein the first phosphatidylcholine and the second phosphatidylcholine differ in one or two fatty acid residues or fatty acid residue derivatives which are esterified to the glycerol backbone of the phosphatidylcholine. In one embodiment the apolipoprotein is selected from an apolipoprotein that has the amino acid sequence selected from SEQ ID NO: 01, 02, 06, 66, and 67, or is a variant thereof that has at least 70 % sequence identity with the selected sequence.本文報導一種包含脂蛋白元、磷脂醯膽鹼及脂質(諸如磷脂、脂肪酸或類固醇脂質)之脂肪顆粒。在一個實施例中，脂肪顆粒僅包含一種脂蛋白元。在一個實施例中，脂肪顆粒由一種脂蛋白元、磷脂、脂質及清潔劑組成。在一個實施例中，脂質為第二磷脂醯膽鹼，其中第一磷脂醯膽鹼及第二磷脂醯膽鹼不同在於酯化至磷脂醯膽鹼之甘油骨架上的一或兩個脂肪酸殘基或脂肪酸殘基衍生物。在一個實施例中，脂蛋白元係選自具有選自SEQ ID NO: 01、02、06、66及67之胺基酸序列的脂蛋白元，或為其變異體，與所選序列具有至少70%序列一致性。
