Pharmaceutical composition for the treatment of diseases of the central and peripheral nervous system of vascular, traumatic, toxic, hypoxic and autoimmune origin
NAZARENKO, Anna Borisovna,SOKOLOV, Mikhail Anatolevich
申请号：
ES11801210
公开号：
ES2671247T3
申请日:
2011.06.09
申请国别(地区):
ES
年份:
2018
代理人:
摘要：
Pharmaceutical composition for use in the treatment of diseases of the central and peripheral nervous system, of vascular, traumatic, toxic, hypoxic and autoimmune origin, in the form of a solution for parenteral, intranasal and subconjunctival administration； in which the active ingredient is the biologically active protein-polypeptide complex of 0.01 to 2.0 mg / ml with the specific reparative effect of the tissue on the nervous tissue, obtainable from the rapidly frozen embryonic brain tissue of mid-first cattle third to the middle of the last third of gestational age, a complex that contains weakly acidic neutral proteins and polypeptides with a negative charge in relation to growth factor, differentiation factor, signaling molecules, which determine their biological and pharmacological activity, with masses molecules of 5 to 200 kDa, in which at least 80% of the total protein mass has the molecular mass of 10 to 120 kDa, and is characterized by a peak in the wavelength of 274-284 nm in the UV spectrum -visible and bands in the range of 4.2 to 8.4 in isoelectric focus on a 5% polyacrylamide gel, and complex containing a pharmaceutically acceptable diluent.Composición farmacéutica para su uso en el tratamiento de enfermedades del sistema nervioso central y periférico, de origen vascular, traumático, tóxico, hipóxico y autoinmune, en forma de solución para la administración parenteral, intranasal y subconjuntival； en la que el principio activo es el complejo proteico-polipeptídico biológicamente activo de 0,01 a 2,0 mg/ml con el efecto reparador específico del tejido sobre el tejido nervioso, obtenible del tejido cerebral embrionario rápidamente congelado de ganado de mediados del primer tercio hasta mediados del último tercio de la edad gestacional, complejo que contiene las proteínas y polipéptidos neutros débilmente ácidos con carga negativa en relación con el factor de crecimiento, factor de diferenciación, moléculas de señalización, que determinan su activida
